Vickie L. Stepp and William F. Skeens are facings charges of possession of a schedule II substance, which is a first-degree felony, and trafficking in drugs, also a first degree felony.
At about 4:31 p.m. Friday, a 1998 Mazda 626 driven by Vickie Stepp was stopped on U.S. 23 in Lucasville on a speed violation.
Portsmouth Post Commander Lt. Mike Crispen said a search of the vehicle revealed 22 30-milligram OxyContin pills under the passenger seat.
A further search of the vehicle revealed 700 30-milligram OxyContin pills in a small container and $2,088 in cash.
The two were incarcerated in Scioto County Jail, and were arraigned Tuesday morning in Portsmouth Municipal Court.
Crispen said both bonded out Wednesday.